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MR Enterography May Identify Histologic Subtypes

June 29, 2009
Written by: , Filed in: Abdominal Imaging
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A recent study was conducted to determine if there are findings on MR enterography that can help radiologists differentiate between the various histologic subtypes of small-bowel lymphoma.

Participants/Methods
The retrospective analysis was comprised of 10 patients with histologically confirmed primary small-bowel lymphoma. There were 4 men and 6 women ranging between 44 and 85 years of age.

Histological confirmation was based on endoscopy, laparoscopy, or laparotomy.

The 3 prognostic categories were low, intermediate, and high grade.

MR enterography was performed on a 1.5 Tesla system and utilized a single protocol.

Coronal and axial true fast imaging with steady-state precession (FISP) sequences were obtained.

Intravenous contrast was not administered. Diluted polyethylene glycol was ingested over a 45-minute period before scanning. Two abdominal radiologists reviewed the images.

Related CME:
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Abdominal & Thoracic CT/MR/US: Optimizing Practice
The University of California, San Francisco School of Medicine
Evolving technology improves radiological practice through improved image quality for anatomical interpretation and generation of functional data. The use of MDCT and fast, multi-phase imaging sequences also translates to a tremendous increase in data that requires review and handling and greater need for contrast and radiation safety awareness. This activity targets the community radiologist involved in body and cardiovascular imaging with a focus on developing an efficient workflow practice in the modern imaging environment.
Read more or order: Abdominal & Thoracic CT/MR/US: Optimizing Practice

CT/MRI of the Abdomen and Pelvis
University of California San Francisco Department of Radiology and Biomedical Imaging
Provides an updated review on the use of helical (single and multidetector-row) CT and MRI for imaging of the abdomen and pelvis. Participants will learn the current approach and uses of CT/MRI in the examination of the abdomen and pelvis including advances in abdominal MRI techniques, genitourinary applications of CT/MRI, CT colonoscopy, CT/MR angiography, and CT cholangiography.
Earn up to 12 AMA PRA Category 1 Credits™.
Abdominal Imaging CME

Results
19 small-bowel segments were involved by non-Hodgkin’s lymphoma (NHL) in these 10 patients. Six out of 10 patients had histologically confirmed celiac disease.

Six of the patients had B-cell origin NHL and included low-grade NHL such as follicular and mucosa-associated lymphoid tissue (MALT), intermediate- to high-grade follicular NHL, and high-grade NHL.

Four patients had T-cell origin, and all of them had underlying celiac disease.

Patients with celiac disease had the longest segments of small bowel wall thickening, averaging 24 cm.

Related CME:
NEW FOR 2009
Abdominal & Thoracic CT/MR/US: Optimizing Practice
The University of California, San Francisco School of Medicine
Evolving technology improves radiological practice through improved image quality for anatomical interpretation and generation of functional data. The use of MDCT and fast, multi-phase imaging sequences also translates to a tremendous increase in data that requires review and handling and greater need for contrast and radiation safety awareness. This activity targets the community radiologist involved in body and cardiovascular imaging with a focus on developing an efficient workflow practice in the modern imaging environment.
Read more or order: Abdominal & Thoracic CT/MR/US: Optimizing Practice

CT/MRI of the Abdomen and Pelvis
University of California San Francisco Department of Radiology and Biomedical Imaging
Provides an updated review on the use of helical (single and multidetector-row) CT and MRI for imaging of the abdomen and pelvis. Participants will learn the current approach and uses of CT/MRI in the examination of the abdomen and pelvis including advances in abdominal MRI techniques, genitourinary applications of CT/MRI, CT colonoscopy, CT/MR angiography, and CT cholangiography.
Earn up to 12 AMA PRA Category 1 Credits™.
Abdominal Imaging CME

There was circumferential bowel wall involvement in at least 1 segment in all 10 patients. Smooth margins were found in all 6 patients with celiac disease, and was not a feature in those without the disease.

A smooth serosal contour was found with both T-cell and B-cell NHL associated with celiac disease. Aneurysmal small-bowel loop dilatation was only found in those patients with celiac disease.

There was 1 patient with celiac T-cell NHL who had luminal narrowing due to intermediate- to high-grade disease.

There was circumferential diffuse distribution and no preferential mesenteric or antimesenteric involvement in 8 of the 19 diseased segments, all of which were identified in patients with celiac disease.

Mesenteric fat infiltration without discrete lymphadenopathy was only identified in patients with high-grade NHL.

No significant difference was seen in signal intensity between lesions in patients with and without celiac disease.

Conclusion
Non-Hodgkin’s lymphoma associated with celiac disease has a tendency to manifest as a single, long, smooth, continuous bowel segment, often with aneurysmal dilatation.

Reviewer’s Comments
These results are useful in that they demonstrate a few characteristics of small-bowel lymphoma on MR enterography that can help suggest a certain histologic subtype and whether there is underlying celiac disease.

These findings would provide for a challenging initial imaging diagnosis. However, there are not likely to be any immediate clinical implications, as management would still rely on the final diagnosis by histologic confirmation. One limitation of the study is its small simple size.

Author: John C. Sabatino, MD

Reference:
Lohan DG, Alhajeri AN, et al. MR Enterography of Small-Bowel Lymphoma: Potential for Suggestion of a Histologic Subtype and the Presence of Underlying Celiac Disease. AJR; 2008; 190 (February): 287-293

Related CME:
NEW FOR 2009
Abdominal & Thoracic CT/MR/US: Optimizing Practice
The University of California, San Francisco School of Medicine
Evolving technology improves radiological practice through improved image quality for anatomical interpretation and generation of functional data. The use of MDCT and fast, multi-phase imaging sequences also translates to a tremendous increase in data that requires review and handling and greater need for contrast and radiation safety awareness. This activity targets the community radiologist involved in body and cardiovascular imaging with a focus on developing an efficient workflow practice in the modern imaging environment.
Read more or order: Abdominal & Thoracic CT/MR/US: Optimizing Practice

CT/MRI of the Abdomen and Pelvis
University of California San Francisco Department of Radiology and Biomedical Imaging
Provides an updated review on the use of helical (single and multidetector-row) CT and MRI for imaging of the abdomen and pelvis. Participants will learn the current approach and uses of CT/MRI in the examination of the abdomen and pelvis including advances in abdominal MRI techniques, genitourinary applications of CT/MRI, CT colonoscopy, CT/MR angiography, and CT cholangiography.
Earn up to 12 AMA PRA Category 1 Credits™.
Abdominal Imaging CME
.
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