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Subpleural Lung Cysts Prevalent in Children With Down Syndrome

April 19, 2008
Written by: , Filed in: Chest Radiology, Pediatric Radiology
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The objective of a recent study was to better define the prevalence and location of subpleural cysts in children with Down syndrome and to assess the cysts’ associations with coexistent diagnoses.

The retrospective study has concluded that subpleural cysts are a common finding on chest CT in children with Down syndrome.

Methodology
Children with Down syndrome who had undergone chest CT over an eight-year period were identified. CT examinations were performed according to the standard clinical protocol at the time of the examination. All but two of the scans were performed with intravenous contrast.

The scans were analyzed independently by two radiologists for the presence or absence of subpleural cysts, location of the cysts, and the presence of intraparenchymal cysts. Patient charts were also reviewed for information regarding gender, age at time of CT imaging, coexistent diagnoses, past treatments with ventilator support, or extra corporeal membrane oxygenation.

Review for Practicing Radiologists The University of California, San Francisco School of Medicine, Department of Radiology and Biomedical Imaging Review for Practicing Radiologists an intensive clinical radiologic review and self-assessment covering the following radiology subspecialties: Vascular-Interventional, Breast, Neuro, Gastrointestinal and Pulmonary Imaging. The program is designed for radiologists in clinical practice. Click here to read more or order: Review for Practicing Radiologists --

 

Body Imaging: Abdominal, Thoracic and Vascular University of California, San Francisco, Department of Radiology Course Director: Judy Yee, MD This program is designed for the radiologist in clinical practice, and is intended to provide an overview and update on clinically relevant topics in diagnostic imaging and interventional techniques. Click here to read more or order: Body Imaging

Results of the Study
Twenty-five children were identified, who ranged in age from three months to 20 years. Among these children, 36% had subpleural cysts. All of the cysts were located in the antero medial portion of the lung, with 44% of the children also having cysts along the fissures. Of the children with subpleural cysts, 22% had a history of prematurity, 89% had a history of congenital heart disease, and 44% had a history of chronic ventilator support.

Conclusions
Subpleural cysts within the lungs are a common finding on chest CT in children with Down syndrome. They are most commonly located within the antero medial portion of the lung.

Reviewer’s Comments
This was an interesting initial investigation into this topic. The prevalence of subpleural cysts on CT has not been described before, and its clinical implications remain elusive.

Author: Basil Hubbi, MD

Reference
Biko DM, Schwartz M, et al. Subpleural Lung Cysts in Down Syndrome: Prevalence and Association With Coexisting Diagnoses. Pediatr Radiol; 2008; 38 (March): 280-284:
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Review for Practicing Radiologists The University of California, San Francisco School of Medicine, Department of Radiology and Biomedical Imaging Review for Practicing Radiologists an intensive clinical radiologic review and self-assessment covering the following radiology subspecialties: Vascular-Interventional, Breast, Neuro, Gastrointestinal and Pulmonary Imaging. The program is designed for radiologists in clinical practice. Click here to read more or order: Review for Practicing Radiologists --

 

Body Imaging: Abdominal, Thoracic and Vascular University of California, San Francisco, Department of Radiology Course Director: Judy Yee, MD This program is designed for the radiologist in clinical practice, and is intended to provide an overview and update on clinically relevant topics in diagnostic imaging and interventional techniques. Click here to read more or order: Body Imaging
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